Simulating the time series of a selected gene expression profile in an agent-based tumor model

نویسندگان

  • Yuri Mansury
  • Thomas S. Deisboeck
چکیده

1 Complex Biosystems Modeling Laboratory, Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, HST-Biomedical Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139; 2 Molecular NeuroOncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; 3 Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Multivariate Feature Extraction for Prediction of Future Gene Expression Profile

Introduction: The features of a cell can be extracted from its gene expression profile. If the gene expression profiles of future descendant cells are predicted, the features of the future cells are also predicted. The objective of this study was to design an artificial neural network to predict gene expression profiles of descendant cells that will be generated by division/differentiation of h...

متن کامل

Multivariate Feature Extraction for Prediction of Future Gene Expression Profile

Introduction: The features of a cell can be extracted from its gene expression profile. If the gene expression profiles of future descendant cells are predicted, the features of the future cells are also predicted. The objective of this study was to design an artificial neural network to predict gene expression profiles of descendant cells that will be generated by division/differentiation of h...

متن کامل

Optimization of Gene Expression Programming Model using Wavelet Transform for Simulating Long-term Rainfall in Anzali City

Due to drought and climate change, estimation and prediction of rainfall is quite important in various areas all over the world. In this study, a novel artificial intelligence (AI) technique (WGEP) was developed to model long-term rainfall (67 years period) in Anzali city for the first time. This model was combined using Wavelet Transform (WT) and Gene Expression Programming (GEP) model. Firstl...

متن کامل

Down-regulation of HSP40 gene family following OCT4B1 suppression in human tumor cell lines

Objective(s): The OCT4B1, as one of OCT4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. The present study was designed to determine the effects of OCT4B1 silencing on expressional profile of HSP40 gene family expression in three different human tumor cell lines. Materials and Met...

متن کامل

An Agent- based Modeling for Breast Tissue Simulation and the Growth and Spread of Tumor in Various Breast Cancer States

Introduction: Breast cancer is a cancer that is caused by abnormal growth of breast cells. Modeling  and simulation of the growth and treatment of breast cancer, along with providing the possibility of doing experiments and research, can reduce the time and cost of treatment by predicting some cases. The purpose of the present research was to develop an agent-based model for the simulation of b...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2003